一、基本信息
李享，讲师
研究领域：制药工程与化学生物学
电子邮件：Lixiang199284@hubu.edu.cn
二、教育背景及工作经历
2010.09-2014.06，华中科技大学，应用化学，学士
2014.09-2019.12，华中师范大学，生物无机化学，博士，导师：刘长林
2020.05-2022.05，北京大学，化学与分子工程学院，博雅博士后，合作导师：陈兴
2022.07-至今，304am永利集团，化学化工学院，制药工程系，教师
三、研究方向
基于胞内活性氧物种（ROS）水平的调控，开发选择性抗癌试剂；基于基因组学、转录组学、蛋白组学的整合研究策略，分析癌症治疗过程中的生物学机制及相关问题；基于多组学的研究策略，分析基因表达调控的相关机理；开发基于配位化学的新型抗癌试剂或药物，并分析潜在的作用机理。
四、代表性论文
1. Li, X.*, Qiu, S.*, Shi, J., Wang, S., Wang, M., Xu, Y., ... & Liu, C.# (2019). A new function of copper zinc superoxide dismutase: as a regulatory DNA-binding protein in gene expression in response to intracellular hydrogen peroxide. Nucleic Acids Research, 47, 5074-5085.
2. Yang, Y., Li, M., Chen, G., Liu, S., Guo, H., Dong, X., ... & Li, X.# (2023). Dissecting copper biology and cancer treatment:‘Activating Cuproptosis or suppressing Cuproplasia’. Coordination Chemistry Reviews, 495, 215395.
3. Hao, Y.*, Li, X.*, Qin, K., Shi, Y., He, Y., Zhang, C., ... & Chen, X. (2023). Chemoproteomic and Transcriptomic Analysis Reveals that O‐GlcNAc Regulates Mouse Embryonic Stem Cell Fate through the Pluripotency Network. Angewandte Chemie International Edition,135(17), e202300500.
4. Dong, X.*, Wang, H.*, Zhang, H., Li, M., Huang, Z., Qian, W.#, & Li, X.# (2022) Copper-thiosemicarbazone complexes conjugated-cellulose fibers: Biodegradable materials with antibacterial capacity. Carbohydrate Polymers, 294, 119839.
5. Yang, Y., Liang, S., Geng, H., Xiong, M., Li, M., Su, Q., ... & Li, X.# (2022). Proteomics revealed the crosstalk between copper stress and cuproptosis, and explored the feasibility of curcumin as anticancer copper ionophore. Free Radical Biology and Medicine, 193, 638-647.
6. Shi, J., Wang, H., Wang, Y., Peng, Y., Huang, X., Zhang, Y., ... Li, X.# & Liu, C.# (2023). Mitochondrion-targeting and in situ photocontrolled protein delivery via photocages. Journal of Photochemistry and Photobiology B: Biology, 238, 112624.
7. Li, X., Li, J., Dong, X., Gao, X., Zhang, D.#, & Liu, C.# (2017). A novel 3-Hydroxychromone fluorescence sensor for intracellular Zn2+ and its application in the recognition of prostate cancer cells. Sensors and Actuators B: Chemical, 245, 129-136.
8. Hu, Y.*, Li, X.*, Zhang, Z., Chen, G., Liang, H., Zhang, D.#, & Liu, C.# (2018). Detection of hydrogen sulphide based on a novel G-quadruplex selective fluorescent probe. Sensors and Actuators B: Chemical, 272, 308-313.
